Colorectal or colon cancer is a significant cause of mortality in Western populations.This cancer develops as a result of the pathologic transformation of normal colonic epithelium to an adenomatous polyp and ultimately an invasive cancer. Like most cancers, colorectal cancers have multiple causes, many of which remain unknown. Each of these conditions is caused in part by a known genetic mutation. Mutations in two classes of genes, tumour suppressor genes (TSGs) and proto oncogenes are thought to impart a proliferative advantage to cells and contribute to development of the malignant phenotype development and differentiation. Mutations are alterations in genetic material and take place in the genes, which are found in the long, chain like molecules of deoxyribonucleic acid (DNA). Genetic damage that occurs to these genes contributes to the development of a cancerous tumour.
MATCH goal is the development of an automated diagnosis system concerning the support of the treatment of colon carcinoma.The whole process is associated with the field of biological therapies for colon cancer tumours.The colon cancer automated diagnosis system (by discovering mutations on TSGs) is a computer based platform that addresses doctors, biologists, cancer researchers, pharmaceutical companies and medical staff.
For further information, please visit:
http://www.match-project.com
Project co-ordinator:
FONDAZIONE ISTITUTO ONCOLOGICO DEL MEDITERRANEO
Partners:
- Fondazione IOM (IT)
- University of Patras (GR)
- Spirit A.E. (GR)
- TBS G.B.Telematic &Biomadical Services Limited (UK)
- Sineura Spa (IT)
- Sheffield Hallam University (UK)
- Team Consulting Polska Sp.zo.o (PL)
- Jagiellonski University (PL)
Timetable: from 01/06 to 07/08
Total cost: 2.974.889
EC funding: 2.015. 033
Instrument: STREP
Project Identifier: IST-2005-027266