Biomax will provide their BioXM™ Knowledge Management Environment to integrate and explore existing knowledge sources about brain structure and function, extend them with information about psychosis and genetic factors derived from the BioLT™ literature-mining software, and combine them with data generated within the METSY project itself including brain imaging (combined MRI and PET), metabolite profiling, and clinical data from approximately 500 patients recruited at four sites in Spain, the United Kingdom and Finland.
The resulting semantic network of psychosis-specific knowledge - generated from associations between structures, functions and molecules (genes, proteins, metabolites, etc.) - can be overlaid with patient-specific data. The standardization of information and data provided by the BioXM system enables algorithmic analysis and fosters collaboration with external, large-scale brain imaging and systems medicine initiatives. In particular, the METSY partners will use network inference to identify and evaluate multi-modal blood and neuroimaging biomarkers that could be used to predict and monitor psychotic disorders like schizophrenia in the context of metabolic diseases. If specific disease-associated patterns are detected in the project, the network can be further explored for potential explanations. After validation, the knowledge base can be used to build a decision support system to bring the results directly into clinical practice.
About METSY
METSY is a European consortium studying the links between psychotic disorders, lipid metabolism and metabolic co-morbidities such as metabolic syndrome and diabetes. The consortium aims to develop neuroimaging and bioinformatics tools to identify possible diagnostic biomarkers of psychosis.
Funded in part by the EU's Seventh Framework Programme, which provided ~€4.23 million of the €5.94 million total budget, the METSY consortium involves seven members who provide the remainder of the funding: VTT Technical Research Center of Finland, University of Turku, Finland's National Institute for Health and Welfare, Kings College London, Madrid Health Service, Philips Research and Biomax Informatics.
About Biomax Informatics AG
Biomax Informatics AG is a leader in the development of computational solutions for the life sciences. Biomax provides the BioXM™ Knowledge Management Environment and other computational solutions, including the Viscovery® data-mining technology, for better decision making and knowledge management in biomarker identification, patient stratification and targeted medicine.