Their report, appearing in the July 12 issue of Science Robotics, maps some of the ethical considerations for governments, policy makers, technologists, and clinicians, and urges stakeholders to come together to rapidly develop guidelines for trust, agency, engagement, and real-world efficacy.
Knowing a tumor's molecular type enables neurosurgeons to make decisions such as how much brain tissue to remove and whether to place tumor-killing drugs directly into the brain - while the patient is still on the operating table.
The study by researchers at New York University, Columbia Engineering, and the New York Genome Center, combines a deep learning model with CRISPR screens to control the expression of human genes in different ways - such as flicking a light switch to shut them off completely or by using a dimmer knob to partially turn down their activity.